Serum and Urinary NGAL in Septic Newborns
Joint Authors
Jadamus-Niebroj, Danuta
Wroblewska, Jolanta
Maruniak-Chudek, Iwona
Brzozowska, Aniceta
Smertka, Mike
Suchojad, Anna
Majcherczyk, Malgorzata
Owsianka-Podlesny, Teresa
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Neutrophil gelatinase-associated lipocalin (NGAL) is postulated to be a potentially new and highly specific/sensitive marker of acute kidney injury (AKI).
The aim of this study was to assess the impact of inflammation on serum and urine NGAL in newborns that were treated due to infection.
We determined serum and urine NGAL concentrations in 73 infants (51 with sepsis; 22 with severe sepsis) admitted to the Intensive Care Unit in the first month of life, for three consecutive days during the course of treatment for infection.
29 neonates without infection served as the control group.
Septic patients, in particular, severe sepsis patients, had increased serum and urinary NGAL levels in the three subsequent days of observation.
Five septic patients who developed AKI had elevated serum and urinary NGAL values to a similar extent as septic neonates without AKI.
A strong correlation was found between the concentration of serum and urinary NGAL and inflammatory markers, such as CRP and procalcitonin.
Serum and urinary NGAL levels were also significantly associated with NTISS (neonatal therapeutic intervention scoring system) values.
We conclude that increased serum and urinary NGAL values are not solely a marker of AKI, and more accurately reflect the severity of inflammatory status.
American Psychological Association (APA)
Smertka, Mike& Wroblewska, Jolanta& Suchojad, Anna& Majcherczyk, Malgorzata& Jadamus-Niebroj, Danuta& Owsianka-Podlesny, Teresa…[et al.]. 2014. Serum and Urinary NGAL in Septic Newborns. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-492982
Modern Language Association (MLA)
Smertka, Mike…[et al.]. Serum and Urinary NGAL in Septic Newborns. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-492982
American Medical Association (AMA)
Smertka, Mike& Wroblewska, Jolanta& Suchojad, Anna& Majcherczyk, Malgorzata& Jadamus-Niebroj, Danuta& Owsianka-Podlesny, Teresa…[et al.]. Serum and Urinary NGAL in Septic Newborns. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-492982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492982