KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats
Joint Authors
Kim, Chan-Sik
Kim, Hyojun
Sohn, Eun Jin
Jeong, Il-Ha
Kim, Jin Sook
Kim, Junghyun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Damage of lens epithelial cells (LECs) has been implicated in cataract formation.
The aim of this study was to investigate the protective effect of KIOM-79, a combination of four plant extracts, on LECs.
We examined the levels of advanced glycation end products (AGEs), nuclear factor-kappaB (NF-κB) activation and inducible nitric oxide synthase (iNOS) expression in LECs during cataract development using the Zucker diabetic fatty (ZDF) rat, an animal model of type 2 diabetes.
KIOM-79 was orally administered by gavage to ZDF rats once a day for 13 weeks.
Apoptosis was detected by TUNEL assay, and NF-κB activation and iNOS expression were studied by southwestern histochemistry and immunohistochemistry, respectively.
In diabetic cataractous lenses, TUNEL-positive LECs were markedly increased 20-fold, and AGEs were highly accumulated (2.7-fold) in LECs.
In addition, both NF-κB activation, and iNOS expression were significantly enhanced 3- to 5-fold, respectively, compared to levels found in normal ZL rats.
However, the administration of KIOM-79 delayed the development of diabetic cataracts and prevented LEC apoptosis (70%) through the inhibition of AGEs, NF-κB-activation and iNOS expression.
These observations suggest that KIOM-79 is useful in inhibiting diabetic cataractogenesis and acts through an antiapoptotic mechanism to protect LECs from injury.
American Psychological Association (APA)
Kim, Junghyun& Kim, Chan-Sik& Sohn, Eun Jin& Kim, Hyojun& Jeong, Il-Ha& Kim, Jin Sook. 2010. KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-493013
Modern Language Association (MLA)
Kim, Junghyun…[et al.]. KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-493013
American Medical Association (AMA)
Kim, Junghyun& Kim, Chan-Sik& Sohn, Eun Jin& Kim, Hyojun& Jeong, Il-Ha& Kim, Jin Sook. KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-493013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493013