Potential Roles of Stevia rebaudiana Bertoni in Abrogating Insulin Resistance and Diabetes : A Review
Joint Authors
Jaapar, Siti Safura
Mohd-Radzman, Nabilatul Hani
Adam, Zainah
Ismail, Wan Iryani Wan
Adam, Aishah
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Insulin resistance is a key factor in metabolic disorders like hyperglycemia and hyperinsulinemia, which are promoted by obesity and may later lead to Type II diabetes mellitus.
In recent years, researchers have identified links between insulin resistance and many noncommunicable illnesses other than diabetes.
Hence, studying insulin resistance is of particular importance in unravelling the pathways employed by such diseases.
In this review, mechanisms involving free fatty acids, adipocytokines such as TNFα and PPARγ and serine kinases like JNK and IKKβ, asserted to be responsible in the development of insulin resistance, will be discussed.
Suggested mechanisms for actions in normal and disrupted states were also visualised in several manually constructed diagrams to capture an overall view of the insulin-signalling pathway and its related components.
The underlying constituents of medicinal significance found in the Stevia rebaudiana Bertoni plant (among other plants that potentiate antihyperglycemic activities) were explored in further depth.
Understanding these factors and their mechanisms may be essential for comprehending the progression of insulin resistance towards the development of diabetes mellitus.
American Psychological Association (APA)
Mohd-Radzman, Nabilatul Hani& Ismail, Wan Iryani Wan& Adam, Zainah& Jaapar, Siti Safura& Adam, Aishah. 2013. Potential Roles of Stevia rebaudiana Bertoni in Abrogating Insulin Resistance and Diabetes : A Review. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-493029
Modern Language Association (MLA)
Mohd-Radzman, Nabilatul Hani…[et al.]. Potential Roles of Stevia rebaudiana Bertoni in Abrogating Insulin Resistance and Diabetes : A Review. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-493029
American Medical Association (AMA)
Mohd-Radzman, Nabilatul Hani& Ismail, Wan Iryani Wan& Adam, Zainah& Jaapar, Siti Safura& Adam, Aishah. Potential Roles of Stevia rebaudiana Bertoni in Abrogating Insulin Resistance and Diabetes : A Review. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-493029
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493029