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Inhibition of Metastatic Potential in Breast Carcinoma In Vivo and In Vitro through Targeting VEGFRs and FGFRs
Joint Authors
Chen, Chih-Hau
Hsiao, Michael
Lee, Liang-Ming
Kuo, Min-Liang
Hua, Kuo-Tai
Wei, Lin-Hung
Chen, Min-Wei
Chien, Ming-Hsien
Lai, Tsung-Ching
Sun, Chung-Ming
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Angiogenesis and lymphangiogenesis are considered to play key roles in tumor metastasis.
Targeting receptor tyrosine kinases essentially involved in the angiogenesis and lymphangiogenesis would theoretically prevent cancer metastasis.
However, the optimal multikinase inhibitor for metastasis suppression has yet to be developed.
In this study, we evaluated the effect of NSTPBP 0100194-A (194-A), a multikinase inhibitor of vascular endothelial growth factor receptors (VEGFRs)/fibroblast growth factor receptors (FGFRs), on lymphangiogenesis and angiogenesis in a mammary fat pad xenograft model of the highly invasive breast cancer cell line 4T1-Luc+.
We investigated the biologic effect of 194-A on various invasive breast cancer cell lines as well as endothelial and lymphatic endothelial cells.
Intriguingly, we found that 194-A drastically reduced the formation of lung, liver, and lymph node metastasis of 4T1-Luc+ and decreased primary tumor growth.
This was associated with significant reductions in intratumoral lymphatic vessel length (LVL) and microvessel density (MVD).
194-A blocked VEGFRs mediated signaling on both endothelial and lymphatic endothelial cells.
Moreover, 194-A significantly inhibited the invasive capacity induced by VEGF-C or FGF-2 in vitro in both 4T1 and MDA-MB231 cells.
In conclusion, these experimental results demonstrate that simultaneous inhibition of VEGFRs/FGFRs kinases may be a promising strategy to prevent breast cancer metastasis.
American Psychological Association (APA)
Chien, Ming-Hsien& Lee, Liang-Ming& Hsiao, Michael& Wei, Lin-Hung& Chen, Chih-Hau& Lai, Tsung-Ching…[et al.]. 2013. Inhibition of Metastatic Potential in Breast Carcinoma In Vivo and In Vitro through Targeting VEGFRs and FGFRs. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-493061
Modern Language Association (MLA)
Chien, Ming-Hsien…[et al.]. Inhibition of Metastatic Potential in Breast Carcinoma In Vivo and In Vitro through Targeting VEGFRs and FGFRs. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-493061
American Medical Association (AMA)
Chien, Ming-Hsien& Lee, Liang-Ming& Hsiao, Michael& Wei, Lin-Hung& Chen, Chih-Hau& Lai, Tsung-Ching…[et al.]. Inhibition of Metastatic Potential in Breast Carcinoma In Vivo and In Vitro through Targeting VEGFRs and FGFRs. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-493061
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493061