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A First Assessment of Mycobacterium tuberculosis Genetic Diversity and Drug-Resistance Patterns in Twelve Caribbean Territories
Joint Authors
Baboolal, Shirematee
Millet, Julie
Rastogi, Nalin
Streit, Elisabeth
Akpaka, Patrick E.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
With the exception of some French-speaking islands, data on tuberculosis (TB) in the Caribbean are scarce.
In this study, we report a first assessment of genetic diversity of a convenience sample of Mycobacterium tuberculosis strains received from twelve Caribbean territories by spoligotyping and describe their drug-resistance patterns.
Of the 480 isolates, 40 (8.3%) isolates showed resistance to at least one anti-TB drug.
The proportion of drug-resistant strains was significantly higher in The Bahamas (21.4%; P=0.02), and Guyana (27.5%; P<0.0001), while it was significantly lower in Jamaica (2.4%; P=0.03) than in other countries of the present study.
Regarding genetic diversity, 104 distinct spoligotype patterns were observed: 49 corresponded to clustered strains (2 to 93 strains per cluster), while 55 remained unclustered among which 16 patterns were not reported previously.
Combining the study results with regional data retrieved from the international SITVIT2 database underlined a connection between frequency of certain M.
tuberculosis phylogenetic lineages and the language spoken, suggesting historical (colonial) and ongoing links (trade, tourism, and migratory flows) with European countries with which they shared a common past.
American Psychological Association (APA)
Millet, Julie& Baboolal, Shirematee& Streit, Elisabeth& Akpaka, Patrick E.& Rastogi, Nalin. 2014. A First Assessment of Mycobacterium tuberculosis Genetic Diversity and Drug-Resistance Patterns in Twelve Caribbean Territories. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-493070
Modern Language Association (MLA)
Millet, Julie…[et al.]. A First Assessment of Mycobacterium tuberculosis Genetic Diversity and Drug-Resistance Patterns in Twelve Caribbean Territories. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-493070
American Medical Association (AMA)
Millet, Julie& Baboolal, Shirematee& Streit, Elisabeth& Akpaka, Patrick E.& Rastogi, Nalin. A First Assessment of Mycobacterium tuberculosis Genetic Diversity and Drug-Resistance Patterns in Twelve Caribbean Territories. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-493070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493070