Organotin Compound Derived from 3-Hydroxy-2-formylpyridine Semicarbazone : Synthesis, Crystal Structure, and Antiproliferative Activity
Joint Authors
Ciunik, Zbigniew
Zervou, Maria
Demertzis, Mavroudis A.
Wietrzyk, Joanna
Kovala-Demertzi, Dimitra
Wiecek, Joanna
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The novel diphenyltin(IV) compound [Ph2(HyFoSc)Sn] (2), where H2HyFoSc (1) is 3-hydroxy-2-formylpyridine semicarbazone, was prepared and characterized by vibrational and NMR (1H, 13C) spectroscopy.
The structure of [Ph2(HyFoSc)Sn] was confirmed by single-crystal X-ray crystallography.
The doubly deprotonated ligand is coordinated to the tin atom through the enolic-oxygen, the azomethine-nitrogen, and phenolic-oxygen, and so acts as an anionic tridentate ligand with the ONO donors.
Two carbon atoms complete the fivefold coordination at the tin(IV) center.
Intermolecular hydrogen bonding, C–H→π, and π→π interactions combine to stabilize the crystal structure.
Compounds 1 and 2 have been evaluated for antiproliferative activity in vitro against the cells of three human tumor cell lines: MCF-7 (human breast cancer cell line), T24 (bladder cancer cell line), A549 (nonsmall cell lung carcinoma), and a mouse fibroblast L-929 cancer cell line.
American Psychological Association (APA)
Wiecek, Joanna& Kovala-Demertzi, Dimitra& Ciunik, Zbigniew& Wietrzyk, Joanna& Zervou, Maria& Demertzis, Mavroudis A.. 2010. Organotin Compound Derived from 3-Hydroxy-2-formylpyridine Semicarbazone : Synthesis, Crystal Structure, and Antiproliferative Activity. Bioinorganic Chemistry and Applications،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-493086
Modern Language Association (MLA)
Wiecek, Joanna…[et al.]. Organotin Compound Derived from 3-Hydroxy-2-formylpyridine Semicarbazone : Synthesis, Crystal Structure, and Antiproliferative Activity. Bioinorganic Chemistry and Applications No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-493086
American Medical Association (AMA)
Wiecek, Joanna& Kovala-Demertzi, Dimitra& Ciunik, Zbigniew& Wietrzyk, Joanna& Zervou, Maria& Demertzis, Mavroudis A.. Organotin Compound Derived from 3-Hydroxy-2-formylpyridine Semicarbazone : Synthesis, Crystal Structure, and Antiproliferative Activity. Bioinorganic Chemistry and Applications. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-493086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493086