Rhodiola crenulata Extract Alleviates Hypoxic Pulmonary Edema in Rats
Joint Authors
Ho, Cheng-Wen
Chang, Tsu-Chung
Shi, Li-Shian
Chu, Hsin
Lee, Shih-Yu
Li, Min-Hui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Sudden exposure of nonacclimatized individuals to high altitude can easily lead to high altitude illnesses.
High altitude pulmonary edema (HAPE) is the most lethal form of high altitude illness.
The present study was designed to investigate the ability of Rhodiola crenulata extract (RCE), an herbal medicine traditionally used as an antiacute mountain sickness remedy, to attenuate hypoxia-induced pulmonary injury.
Exposure of animals to hypobaric hypoxia led to a significant increase in pathological indicators for pulmonary edema, including the lung water content, disruption of the alveolar-capillary barrier, and protein-rich fluid in the lungs.
In addition, hypobaric hypoxia also increased oxidative stress markers, including (ROS) production, (MDA) level, and (MPO) activity.
Furthermore, overexpression of plasma (ET-1), (VEGF) in (BALF), and (HIF-1α) in lung tissue was also found.
However, pretreatment with RCE relieved the HAPE findings by curtailing all of the hypoxia-induced lung injury parameters.
These findings suggest that RCE confers effective protection for maintaining the integrity of the alveolar-capillary barrier by alleviating the elevated ET-1 and VEGF levels; it does so by reducing hypoxia-induced oxidative stress.
Our results offer substantial evidence to support arguments in favor of traditional applications of Rhodiola crenulata for antihigh altitude illness.
American Psychological Association (APA)
Lee, Shih-Yu& Li, Min-Hui& Shi, Li-Shian& Chu, Hsin& Ho, Cheng-Wen& Chang, Tsu-Chung. 2013. Rhodiola crenulata Extract Alleviates Hypoxic Pulmonary Edema in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-493108
Modern Language Association (MLA)
Lee, Shih-Yu…[et al.]. Rhodiola crenulata Extract Alleviates Hypoxic Pulmonary Edema in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-493108
American Medical Association (AMA)
Lee, Shih-Yu& Li, Min-Hui& Shi, Li-Shian& Chu, Hsin& Ho, Cheng-Wen& Chang, Tsu-Chung. Rhodiola crenulata Extract Alleviates Hypoxic Pulmonary Edema in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-493108
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493108