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Arsenic Biotransformation as a Cancer Promoting Factor by Inducing DNA Damage and Disruption of Repair Mechanisms
Joint Authors
Gil, Lionel
Martinez, Victor D.
Vucic, Emily A.
Adonis, Marta
Lam, Wan L.
Source
Molecular Biology International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Chronic exposure to arsenic in drinking water poses a major global health concern.
Populations exposed to high concentrations of arsenic-contaminated drinking water suffer serious health consequences, including alarming cancer incidence and death rates.
Arsenic is biotransformed through sequential addition of methyl groups, acquired from s-adenosylmethionine (SAM).
Metabolism of arsenic generates a variety of genotoxic and cytotoxic species, damaging DNA directly and indirectly, through the generation of reactive oxidative species and induction of DNA adducts, strand breaks and cross links, and inhibition of the DNA repair process itself.
Since SAM is the methyl group donor used by DNA methyltransferases to maintain normal epigenetic patterns in all human cells, arsenic is also postulated to affect maintenance of normal DNA methylation patterns, chromatin structure, and genomic stability.
The biological processes underlying the cancer promoting factors of arsenic metabolism, related to DNA damage and repair, will be discussed here.
American Psychological Association (APA)
Martinez, Victor D.& Vucic, Emily A.& Adonis, Marta& Gil, Lionel& Lam, Wan L.. 2011. Arsenic Biotransformation as a Cancer Promoting Factor by Inducing DNA Damage and Disruption of Repair Mechanisms. Molecular Biology International،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-493126
Modern Language Association (MLA)
Martinez, Victor D.…[et al.]. Arsenic Biotransformation as a Cancer Promoting Factor by Inducing DNA Damage and Disruption of Repair Mechanisms. Molecular Biology International No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-493126
American Medical Association (AMA)
Martinez, Victor D.& Vucic, Emily A.& Adonis, Marta& Gil, Lionel& Lam, Wan L.. Arsenic Biotransformation as a Cancer Promoting Factor by Inducing DNA Damage and Disruption of Repair Mechanisms. Molecular Biology International. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-493126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493126