Polycystic Ovary Syndrome, Insulin Resistance, and Obesity : Navigating the Pathophysiologic Labyrinth
Joint Authors
Mejías, José
Bermúdez, Valmore
Chávez, Mervin
Olivar, Luis
Rojas, Joselyn
Morillo, Jessenia
Rojas, Milagros
Calvo, María
Source
International Journal of Reproductive Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-28
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine-metabolic disorder that implies various severe consequences to female health, including alarming rates of infertility.
Although its exact etiology remains elusive, it is known to feature several hormonal disturbances, including hyperandrogenemia, insulin resistance (IR), and hyperinsulinemia.
Insulin appears to disrupt all components of the hypothalamus-hypophysis-ovary axis, and ovarian tissue insulin resistance results in impaired metabolic signaling but intact mitogenic and steroidogenic activity, favoring hyperandrogenemia, which appears to be the main culprit of the clinical picture in PCOS.
In turn, androgens may lead back to IR by increasing levels of free fatty acids and modifying muscle tissue composition and functionality, perpetuating this IR-hyperinsulinemia-hyperandrogenemia cycle.
Nonobese women with PCOS showcase several differential features, with unique biochemical and hormonal profiles.
Nevertheless, lean and obese patients have chronic inflammation mediating the long term cardiometabolic complications and comorbidities observed in women with PCOS, including dyslipidemia, metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease.
Given these severe implications, it is important to thoroughly understand the pathophysiologic interconnections underlying PCOS, in order to provide superior therapeutic strategies and warrant improved quality of life to women with this syndrome.
American Psychological Association (APA)
Rojas, Joselyn& Chávez, Mervin& Olivar, Luis& Rojas, Milagros& Morillo, Jessenia& Mejías, José…[et al.]. 2014. Polycystic Ovary Syndrome, Insulin Resistance, and Obesity : Navigating the Pathophysiologic Labyrinth. International Journal of Reproductive Medicine،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-493134
Modern Language Association (MLA)
Rojas, Joselyn…[et al.]. Polycystic Ovary Syndrome, Insulin Resistance, and Obesity : Navigating the Pathophysiologic Labyrinth. International Journal of Reproductive Medicine No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-493134
American Medical Association (AMA)
Rojas, Joselyn& Chávez, Mervin& Olivar, Luis& Rojas, Milagros& Morillo, Jessenia& Mejías, José…[et al.]. Polycystic Ovary Syndrome, Insulin Resistance, and Obesity : Navigating the Pathophysiologic Labyrinth. International Journal of Reproductive Medicine. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-493134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493134