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Endometriosis Gene Expression Heterogeneity and Biosignature : A Phylogenetic Analysis
Joint Authors
Amri, Hakima
Abu-Asab, Mones S.
Abu-Asab, Nihad
Amini, Dennis
Zhang, Ming
Source
Obstetrics and Gynecology International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Endometriosis is a multifactorial disease with poorly understood etiology, and reflecting an evolutionary nature where genetic alterations accumulate throughout pathogenesis.
Our objective was to characterize the heterogeneous pathological process using parsimony phylogenetics.
Gene expression microarray data of ovarian endometriosis obtained from NCBI database were polarized and coded into derived (abnormal) and ancestral (normal) states.
Such alterations are referred to as synapomorphies in a phylogenetic sense (or biomarkers).
Subsequent gene linkage was modeled by Genomatix BiblioSphere Pathway software.
A list of clonally shared derived (abnormal) expressions revealed the pattern of heterogeneity among specimens.
In addition, it has identified disruptions within the major regulatory pathways including those involved in cell proliferation, steroidogenesis, angiogenesis, cytoskeletal organization and integrity, and tumorigenesis, as well as cell adhesion and migration.
Furthermore, the analysis supported the potential central involvement of ESR2 in the initiation of endometriosis.
The pathogenesis mapping showed that eutopic and ectopic lesions have different molecular biosignatures.
American Psychological Association (APA)
Abu-Asab, Mones S.& Zhang, Ming& Amini, Dennis& Abu-Asab, Nihad& Amri, Hakima. 2011. Endometriosis Gene Expression Heterogeneity and Biosignature : A Phylogenetic Analysis. Obstetrics and Gynecology International،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-493136
Modern Language Association (MLA)
Abu-Asab, Mones S.…[et al.]. Endometriosis Gene Expression Heterogeneity and Biosignature : A Phylogenetic Analysis. Obstetrics and Gynecology International No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-493136
American Medical Association (AMA)
Abu-Asab, Mones S.& Zhang, Ming& Amini, Dennis& Abu-Asab, Nihad& Amri, Hakima. Endometriosis Gene Expression Heterogeneity and Biosignature : A Phylogenetic Analysis. Obstetrics and Gynecology International. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-493136
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493136