Interpretation of Controversial Teratogenic Findings of Drugs Such As Phenobarbital
Joint Authors
Dudás, Istvan
Bánhidy, Ferenc
Czeizel, Andrew E.
Source
ISRN Obstetrics and Gynecology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To check the debated association between phenobarbital treatment during pregnancy and risk for congenital abnormalities (CAs) in their children.
Study Design.
It is a comparison of phenobarbital treatment in the mothers of cases with CA and matched controls without CAs in the Hungarian Case-Control Surveillance System of Congenital Abnormalities.
Results.
Of 22,843 cases with CA, 149 (0.65%) had mothers with phenobarbital treatment, while of 38,151 control newborn infants without CA, 209 (0.55%) were born to mothers with phenobarbital treatment (100–400 mg daily) (OR with 95% CI : 1.3, 1.1–1.7).
Of 16 CA groups, only hypospadias had a higher risk after phenobarbital treatment in the critical period of this CA (OR with 95% CI : 2.4, 1.1–5.4).
However, if only medically recorded phenobarbital treatments were evaluated and multiple testing bias was considered, this association would disappear.
Conclusions.
This study stresses the importance of the exclusion of recall bias and multiple testing bias.
American Psychological Association (APA)
Czeizel, Andrew E.& Dudás, Istvan& Bánhidy, Ferenc. 2011. Interpretation of Controversial Teratogenic Findings of Drugs Such As Phenobarbital. ISRN Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-493193
Modern Language Association (MLA)
Czeizel, Andrew E.…[et al.]. Interpretation of Controversial Teratogenic Findings of Drugs Such As Phenobarbital. ISRN Obstetrics and Gynecology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-493193
American Medical Association (AMA)
Czeizel, Andrew E.& Dudás, Istvan& Bánhidy, Ferenc. Interpretation of Controversial Teratogenic Findings of Drugs Such As Phenobarbital. ISRN Obstetrics and Gynecology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-493193
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493193