Comparing Quantitative Trait Loci and Gene Expression Data
Joint Authors
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-09-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
We develop methods to compare the positions of quantitative trait loci (QTL) with a set of genes selected by other methods, such as microarray experiments, from a sequenced genome.
We apply our methods to QTL for addictive behavior in mouse, and a set of genes upregulated in a region of the brain associated with addictive behavior, the nucleus accumbens (NA).
The association between the QTL and NA genes is not significantly stronger than expected by chance.
However, chromosomes 2 and 16 do show strong associations suggesting that genes on these chromosomes might be associated with addictive behavior.
The statistical methodology developed for this study can be applied to similar studies to assess the mutual information in microarray and QTL analyses.
American Psychological Association (APA)
Han, Bing& Altman, Naomi S.. 2008. Comparing Quantitative Trait Loci and Gene Expression Data. Advances in Bioinformatics،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-493205
Modern Language Association (MLA)
Han, Bing& Altman, Naomi S.. Comparing Quantitative Trait Loci and Gene Expression Data. Advances in Bioinformatics No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-493205
American Medical Association (AMA)
Han, Bing& Altman, Naomi S.. Comparing Quantitative Trait Loci and Gene Expression Data. Advances in Bioinformatics. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-493205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493205