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Do Aspirin and Other Antiplatelet Drugs Reduce the Mortality in Critically Ill Patients?
Joint Authors
Winning, Johannes
Bauer, Michael
Kabisch, Björn
Lösche, Wolfgang
Claus, Ralf A.
Boettel, Janina
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Platelet activation has been implicated in microvascular thrombosis and organ failure in critically ill patients.
In the first part the present paper summarises important data on the role of platelets in systemic inflammation and sepsis as well as on the beneficial effects of antiplatelet drugs in animal models of sepsis.
In the second part the data of retrospective and prospective observational clinical studies on the effect of aspirin and other antiplatelet drugs in critically ill patients are reviewed.
All of these studies have shown that aspirin and other antiplatelet drugs may reduce organ failure and mortality in these patients, even in case of high bleeding risk.
From the data reviewed here interventional prospective trials are needed to test whether aspirin and other antiplatelet drugs might offer a novel therapeutic option to prevent organ failure in critically ill patients.
American Psychological Association (APA)
Lösche, Wolfgang& Boettel, Janina& Kabisch, Björn& Winning, Johannes& Claus, Ralf A.& Bauer, Michael. 2011. Do Aspirin and Other Antiplatelet Drugs Reduce the Mortality in Critically Ill Patients?. Thrombosis،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-493232
Modern Language Association (MLA)
Lösche, Wolfgang…[et al.]. Do Aspirin and Other Antiplatelet Drugs Reduce the Mortality in Critically Ill Patients?. Thrombosis No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-493232
American Medical Association (AMA)
Lösche, Wolfgang& Boettel, Janina& Kabisch, Björn& Winning, Johannes& Claus, Ralf A.& Bauer, Michael. Do Aspirin and Other Antiplatelet Drugs Reduce the Mortality in Critically Ill Patients?. Thrombosis. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-493232
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493232