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Interleukin-6 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension
Joint Authors
Kuwana, Masataka
Satoh, Toru
Furuya, Yoshiaki
Source
International Journal of Rheumatology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Interleukin-6 (IL-6) is a pleiotropic cytokine with a wide range of biologic activities in immune regulation, hematopoiesis, inflammation, and oncogenesis.
Recent accumulating evidence indicates a pathologic role for IL-6 in promoting proliferation of both smooth muscle and endothelial cells in the pulmonary arterioles, resulting in development of pulmonary arterial hypertension (PAH).
Here, we describe a patient with mixed connective tissue disease and severe, refractory PAH.
Her functional activity and hemodynamic parameters dramatically responded to tocilizumab, a humanized monoclonal antibody to human IL-6 receptor, which was aimed at treating multicentric Castleman's disease.
It appears that IL-6 blockade may hold promise as an adjunct drug in treatment of PAH in idiopathic form as well as in association with connective tissue disease.
American Psychological Association (APA)
Furuya, Yoshiaki& Satoh, Toru& Kuwana, Masataka. 2010. Interleukin-6 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension. International Journal of Rheumatology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-493238
Modern Language Association (MLA)
Furuya, Yoshiaki…[et al.]. Interleukin-6 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension. International Journal of Rheumatology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-493238
American Medical Association (AMA)
Furuya, Yoshiaki& Satoh, Toru& Kuwana, Masataka. Interleukin-6 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension. International Journal of Rheumatology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-493238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493238