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The Interplay between the Bone and the Immune System
Joint Authors
D'Amelio, Patrizia
Brunetti, Giacomina
Faccio, Roberta
Mori, Giorgio
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-14
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
In the last two decades, numerous scientists have highlighted the interactions between bone and immune cells as well as their overlapping regulatory mechanisms.
For example, osteoclasts, the bone-resorbing cells, are derived from the same myeloid precursor cells that give rise to macrophages and myeloid dendritic cells.
On the other hand, osteoblasts, the bone-forming cells, regulate hematopoietic stem cell niches from which all blood and immune cells are derived.
Furthermore, many of the soluble mediators of immune cells, including cytokines and growth factors, regulate the activities of osteoblasts and osteoclasts.
This increased recognition of the complex interactions between the immune system and bone led to the development of the interdisciplinary osteoimmunology field.
Research in this field has great potential to provide a better understanding of the pathogenesis of several diseases affecting both the bone and immune systems, thus providing the molecular basis for novel therapeutic strategies.
In these review, we reported the latest findings about the reciprocal regulation of bone and immune cells.
American Psychological Association (APA)
Mori, Giorgio& D'Amelio, Patrizia& Faccio, Roberta& Brunetti, Giacomina. 2013. The Interplay between the Bone and the Immune System. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-493249
Modern Language Association (MLA)
Mori, Giorgio…[et al.]. The Interplay between the Bone and the Immune System. Clinical and Developmental Immunology No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-493249
American Medical Association (AMA)
Mori, Giorgio& D'Amelio, Patrizia& Faccio, Roberta& Brunetti, Giacomina. The Interplay between the Bone and the Immune System. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-493249
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493249