Iron and Mechanisms of Neurotoxicity
Joint Authors
Uranga, Romina M.
Giusto, Norma M.
Salvador, Gabriela A.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The accumulation of transition metals (e.g., copper, zinc, and iron) and the dysregulation of their metabolism are a hallmark in the pathogenesis of several neurodegenerative diseases.
This paper will be focused on the mechanism of neurotoxicity mediated by iron.
This metal progressively accumulates in the brain both during normal aging and neurodegenerative processes.
High iron concentrations in the brain have been consistently observed in Alzheimer's (AD) and Parkinson's (PD) diseases.
In this connection, metalloneurobiology has become extremely important in establishing the role of iron in the onset and progression of neurodegenerative diseases.
Neurons have developed several protective mechanisms against oxidative stress, among them, the activation of cellular signaling pathways.
The final response will depend on the identity, intensity, and persistence of the oxidative insult.
The characterization of the mechanisms mediating the effects of iron-induced increase in neuronal dysfunction and death is central to understanding the pathology of a number of neurodegenerative disorders.
American Psychological Association (APA)
Salvador, Gabriela A.& Uranga, Romina M.& Giusto, Norma M.. 2010. Iron and Mechanisms of Neurotoxicity. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-493264
Modern Language Association (MLA)
Salvador, Gabriela A.…[et al.]. Iron and Mechanisms of Neurotoxicity. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-493264
American Medical Association (AMA)
Salvador, Gabriela A.& Uranga, Romina M.& Giusto, Norma M.. Iron and Mechanisms of Neurotoxicity. International Journal of Alzheimer's Disease. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-493264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493264