Regulatory Role of GSK-3β on NF-κB, Nitric Oxide, and TNF-α in Group A Streptococcal Infection
Joint Authors
Chang, Yu-Tzu
Lu, Shiou-Ling
Lin, Yee-Shin
Kuo, Chih-Feng
Lin, Chiou-Feng
Chen, Chia-Ling
Cheng, Miao-Huei
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Group A streptococcus (GAS) imposes a great burden on humans.
Efforts to minimize the associated morbidity and mortality represent a critical issue.
Glycogen synthase kinase-3β (GSK-3β) is known to regulate inflammatory response in infectious diseases.
However, the regulation of GSK-3β in GAS infection is still unknown.
The present study investigates the interaction between GSK-3β, NF-κB, and possible related inflammatory mediators in vitro and in a mouse model.
The results revealed that GAS could activate NF-κB, followed by an increased expression of inducible nitric oxide synthase (iNOS) and NO production in a murine macrophage cell line.
Activation of GSK-3β occurred after GAS infection, and inhibition of GSK-3β reduced iNOS expression and NO production.
Furthermore, GSK-3β inhibitors reduced NF-κB activation and subsequent TNF-α production, which indicates that GSK-3β acts upstream of NF-κB in GAS-infected macrophages.
Similar to the in vitro findings, administration of GSK-3β inhibitor in an air pouch GAS infection mouse model significantly reduced the level of serum TNF-α and improved the survival rate.
The inhibition of GSK-3β to moderate the inflammatory effect might be an alternative therapeutic strategy against GAS infection.
American Psychological Association (APA)
Chang, Yu-Tzu& Chen, Chia-Ling& Lin, Chiou-Feng& Lu, Shiou-Ling& Cheng, Miao-Huei& Kuo, Chih-Feng…[et al.]. 2013. Regulatory Role of GSK-3β on NF-κB, Nitric Oxide, and TNF-α in Group A Streptococcal Infection. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-493267
Modern Language Association (MLA)
Chang, Yu-Tzu…[et al.]. Regulatory Role of GSK-3β on NF-κB, Nitric Oxide, and TNF-α in Group A Streptococcal Infection. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-493267
American Medical Association (AMA)
Chang, Yu-Tzu& Chen, Chia-Ling& Lin, Chiou-Feng& Lu, Shiou-Ling& Cheng, Miao-Huei& Kuo, Chih-Feng…[et al.]. Regulatory Role of GSK-3β on NF-κB, Nitric Oxide, and TNF-α in Group A Streptococcal Infection. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-493267
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493267