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A Valepotriate Fraction of Valeriana glechomifolia Shows Sedative and Anxiolytic Properties and Impairs Recognition But Not Aversive Memory in Mice
Joint Authors
Rech, Sandra Beatriz
Reolon, Gustavo Kellermann
Maurmann, Natasha
Fett-Neto, Arthur Germano
Roesler, Rafael
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Plants of the genus Valeriana (Valerianaceae) are used in traditional medicine as a mild sedative, antispasmodic and tranquilizer in many countries.
This study was undertaken to explore the neurobehavioral effects of systemic administration of a valepotriate extract fraction of known quantitative composition of Valeriana glechomifolia (endemic of southern Brazil) in mice.
Adult animals were treated with a single intraperitoneal injection of valepotriate fraction (VF) in the concentrations of 1, 3 or 10 mg kg-1, or with vehicle in the pre-training period before each behavioral test.
During the exploration of an open field, mice treated with 10 mg kg-1 of VF showed reduced locomotion and exploratory behavior.
Although overall habituation sessions for locomotion and exploratory behavior among vehicle control and doses of VF were not affected, comparison between open-field and habituation sessions within each treatment showed that VF administration at 1 and 10 mg kg-1 impaired habituation.
In the elevated plus-maze test, mice treated with VF (10 mg kg-1) showed a significant increase in the percentage of time spent in the open arms without significant effects in the number of total arm entries.
VF at 3 mg kg-1 produced an impairment of novel-object recognition memory.
In contrast, VF did not affect fear-related memory assessed in an inhibitory avoidance task.
The results indicate that VF can have sedative effects and affect behavioral parameters related to recognition memory.
American Psychological Association (APA)
Maurmann, Natasha& Reolon, Gustavo Kellermann& Rech, Sandra Beatriz& Fett-Neto, Arthur Germano& Roesler, Rafael. 2011. A Valepotriate Fraction of Valeriana glechomifolia Shows Sedative and Anxiolytic Properties and Impairs Recognition But Not Aversive Memory in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-493286
Modern Language Association (MLA)
Maurmann, Natasha…[et al.]. A Valepotriate Fraction of Valeriana glechomifolia Shows Sedative and Anxiolytic Properties and Impairs Recognition But Not Aversive Memory in Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-493286
American Medical Association (AMA)
Maurmann, Natasha& Reolon, Gustavo Kellermann& Rech, Sandra Beatriz& Fett-Neto, Arthur Germano& Roesler, Rafael. A Valepotriate Fraction of Valeriana glechomifolia Shows Sedative and Anxiolytic Properties and Impairs Recognition But Not Aversive Memory in Mice. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-493286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493286