TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction
Joint Authors
Yin, Kai
Zhang, Jianxin
Dang, Shengchun
Shen, Yao
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Severe acute pancreatitis (SAP) can cause intestinal barrier dysfunction (IBD), which significantly increases the disease severity and risk of mortality.
We hypothesized that the innate immunity- and inflammatory-related protein-triggering receptor expressed on myeloid cells-1 (TREM-1) contributes to this complication of SAP.
Thus, we investigated the effect of TREM-1 pathway modulation on a rat model of pancreatitis-associated IBD.
In this study we sought to clarify the role of TREM-1 in the pathophysiology of intestinal barrier dysfunction in SAP.
Specifically, we evaluated levels of serum TREM-1 and membrane-bound TREM-1 in the intestine and pancreas from an animal model of experimentally induced SAP.
TREM-1 pathway blockade by LP17 treatment may suppress pancreatitis-associated IBD and ameliorate the damage to the intestinal mucosa barrier.
American Psychological Association (APA)
Dang, Shengchun& Shen, Yao& Yin, Kai& Zhang, Jianxin. 2012. TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-493288
Modern Language Association (MLA)
Dang, Shengchun…[et al.]. TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction. Gastroenterology Research and Practice No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-493288
American Medical Association (AMA)
Dang, Shengchun& Shen, Yao& Yin, Kai& Zhang, Jianxin. TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-493288
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493288