![](/images/graphics-bg.png)
Correlation of Dynamic PET and Gene Array Data in Patients with Gastrointestinal Stromal Tumors
Joint Authors
Hohenberger, Peter
Pan, Leyun
Strauss, Ludwig G.
Koczan, Dirk
Dimitrakopoulou-Strauss, Antonia
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Introduction.
The results obtained with dynamic PET (dPET) were compared to gene expression data obtained in patients with gastrointestinal stromal tumors (GIST).
The primary aim was to assess the association of the dPET results and gene expression data.
Material and Methods.
dPET was performed following the injection of F-18-fluorodeoxyglucose (FDG) in 22 patients with GIST.
All patients were examined prior to surgery for staging purpose.
Compartment and noncompartment models were used for the quantitative evaluation of the dPET examinations.
Gene array data were based on tumor specimen obtained by surgery after the PET examinations.
Results.
The data analysis revealed significant correlations for the dPET parameters and the expression of zinc finger genes (znf43, znf85, znf91, znf189).
Furthermore, the transport of FDG (k1) was associated with VEGF-A.
The cell cycle gene cyclin-dependent kinase inhibitor 1C was correlated with the maximum tracer uptake (SUVmax) in the tumors.
Conclusions.
The data demonstrate a dependency of the tracer kinetics on genes associated with prognosis in GIST.
Furthermore, angiogenesis and cell proliferation have an impact on the tracer uptake.
American Psychological Association (APA)
Strauss, Ludwig G.& Dimitrakopoulou-Strauss, Antonia& Koczan, Dirk& Pan, Leyun& Hohenberger, Peter. 2012. Correlation of Dynamic PET and Gene Array Data in Patients with Gastrointestinal Stromal Tumors. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-493319
Modern Language Association (MLA)
Strauss, Ludwig G.…[et al.]. Correlation of Dynamic PET and Gene Array Data in Patients with Gastrointestinal Stromal Tumors. The Scientific World Journal No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-493319
American Medical Association (AMA)
Strauss, Ludwig G.& Dimitrakopoulou-Strauss, Antonia& Koczan, Dirk& Pan, Leyun& Hohenberger, Peter. Correlation of Dynamic PET and Gene Array Data in Patients with Gastrointestinal Stromal Tumors. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-493319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493319