Inflammatory Regulation of Valvular Remodeling : The Good(?), the Bad, and the Ugly
Joint Authors
Mahler, Gretchen J.
Butcher, Jonathan T.
Source
International Journal of Inflammation
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Heart valve disease is unique in that it affects both the very young and very old, and does not discriminate by financial affluence, social stratus, or global location.
Research over the past decade has transformed our understanding of heart valve cell biology, yet still more remains unclear regarding how these cells respond and adapt to their local microenvironment.
Recent studies have identified inflammatory signaling at nearly every point in the life cycle of heart valves, yet its role at each stage is unclear.
While the vast majority of evidence points to inflammation as mediating pathological valve remodeling and eventual destruction, some studies suggest inflammation may provide key signals guiding transient adaptive remodeling.
Though the mechanisms are far from clear, inflammatory signaling may be a previously unrecognized ally in the quest for controlled rapid tissue remodeling, a key requirement for regenerative medicine approaches for heart valve disease.
This paper summarizes the current state of knowledge regarding inflammatory mediation of heart valve remodeling and suggests key questions moving forward.
American Psychological Association (APA)
Mahler, Gretchen J.& Butcher, Jonathan T.. 2011. Inflammatory Regulation of Valvular Remodeling : The Good(?), the Bad, and the Ugly. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-493334
Modern Language Association (MLA)
Mahler, Gretchen J.& Butcher, Jonathan T.. Inflammatory Regulation of Valvular Remodeling : The Good(?), the Bad, and the Ugly. International Journal of Inflammation No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-493334
American Medical Association (AMA)
Mahler, Gretchen J.& Butcher, Jonathan T.. Inflammatory Regulation of Valvular Remodeling : The Good(?), the Bad, and the Ugly. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-493334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493334