Zinc Metalloproteinases and Amyloid Beta-Peptide Metabolism : The Positive Side of Proteolysis in Alzheimer's Disease
Joint Authors
Gough, Mallory
Parr-Sturgess, Catherine
Parkin, Edward
Source
Biochemistry Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (Aβ-)peptides in the brain causing progressive neuronal death.
Aβ-peptides are produced by aspartyl proteinase-mediated cleavage of the larger amyloid precursor protein (APP).
In contrast to this detrimental “amyloidogenic” form of proteolysis, a range of zinc metalloproteinases can process APP via an alternative “nonamyloidogenic” pathway in which the protein is cleaved within its Aβ region thereby precluding the formation of intact Aβ-peptides.
In addition, other members of the zinc metalloproteinase family can degrade preformed Aβ-peptides.
As such, the zinc metalloproteinases, collectively, are key to downregulating Aβ generation and enhancing its degradation.
It is the role of zinc metalloproteinases in this “positive side of proteolysis in Alzheimer's disease” that is discussed in the current paper.
American Psychological Association (APA)
Gough, Mallory& Parr-Sturgess, Catherine& Parkin, Edward. 2010. Zinc Metalloproteinases and Amyloid Beta-Peptide Metabolism : The Positive Side of Proteolysis in Alzheimer's Disease. Biochemistry Research International،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-493338
Modern Language Association (MLA)
Gough, Mallory…[et al.]. Zinc Metalloproteinases and Amyloid Beta-Peptide Metabolism : The Positive Side of Proteolysis in Alzheimer's Disease. Biochemistry Research International No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-493338
American Medical Association (AMA)
Gough, Mallory& Parr-Sturgess, Catherine& Parkin, Edward. Zinc Metalloproteinases and Amyloid Beta-Peptide Metabolism : The Positive Side of Proteolysis in Alzheimer's Disease. Biochemistry Research International. 2010. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-493338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493338