Schizandrin, an Antioxidant Lignan from Schisandra chinensis, Ameliorates Aβ1–42-Induced Memory Impairment in Mice
Joint Authors
Hu, Di
Cao, Yunfeng
Yin, Jun
Miao, Lijing
Liu, Zhihui
He, Rong-Rong
Han, Na
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
In the present study, we examined the effect of schisandrin (SCH) of Schisandra chinensis on the amyloid-beta1–42- (Aβ1–42-) induced memory impairment in mice and elucidated the possible antioxidative mechanism.
Mice were intracerebroventricular (i.c.v.) injected with the aggregated Aβ1–42 and then treated with SCH (4, 12, and 36 mg/kg body weight) or donepezil (DPZ), a reference drug (0.65 mg/kg) by intragastric infusion for 14 days.
Noncognitive disturbances and cognitive performance were evaluated by locomotor activity test, Y-maze test, and water maze test.
Antioxidative enzyme activities including superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) and levels of malondialdehyde (MDA), glutathione (GSH), and oxidized glutathione (GSSG) within the cerebral cortex and hippocampus of mice were measured to elucidate the mechanism.
Our results showed that SCH significantly improved Aβ1–42-induced short-term and spatial reference memory impairments in Y-maze test and water maze test.
Furthermore, in the cerebral cortex and hippocampus of mice, SOD and GSH-px activities, GSH level, and GSH/GSSG ratio were increased, and levels of MDA and GSSG were decreased by the treatment of SCH.
These results suggest that SCH is a potential cognitive enhancer against Alzheimer’s disease through antioxidative action.
American Psychological Association (APA)
Hu, Di& Cao, Yunfeng& He, Rong-Rong& Han, Na& Liu, Zhihui& Miao, Lijing…[et al.]. 2012. Schizandrin, an Antioxidant Lignan from Schisandra chinensis, Ameliorates Aβ1–42-Induced Memory Impairment in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-493369
Modern Language Association (MLA)
Hu, Di…[et al.]. Schizandrin, an Antioxidant Lignan from Schisandra chinensis, Ameliorates Aβ1–42-Induced Memory Impairment in Mice. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-493369
American Medical Association (AMA)
Hu, Di& Cao, Yunfeng& He, Rong-Rong& Han, Na& Liu, Zhihui& Miao, Lijing…[et al.]. Schizandrin, an Antioxidant Lignan from Schisandra chinensis, Ameliorates Aβ1–42-Induced Memory Impairment in Mice. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-493369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493369