Docking Studies and Biological Activity of Fosinopril Analogs
Joint Authors
Kini, Suvarna G.
Ranganath Pai Karkala, Sreedhara
Mubeen, Muhammad
Choudary, Jayant
Source
International Journal of Medicinal Chemistry
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The purpose of the present study was to determine the angiotensin-I converting enzyme inhibitory activity of few novel Fosinopril derivatives which were predicted to possess better ACE inhibitory activity and lesser side effects than the existing drug molecule.
In vitro study was carried out to determine ACE inhibitory activity of six different Fosinopril analogs by spectrophotometric assay procedure.
Analog A2 showed the highest activity compared to other analogs and as well as Fosinopril itself.
Docking studies of the compounds were done with the help of VLife MDS 3.0 software using GRIP batch docking method to find out which derivative had a better docking with ACE.
The compounds which showed the highest negative score in docking have also exhibited good ACE inhibitory activity.
American Psychological Association (APA)
Choudary, Jayant& Kini, Suvarna G.& Ranganath Pai Karkala, Sreedhara& Mubeen, Muhammad. 2014. Docking Studies and Biological Activity of Fosinopril Analogs. International Journal of Medicinal Chemistry،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-493379
Modern Language Association (MLA)
Choudary, Jayant…[et al.]. Docking Studies and Biological Activity of Fosinopril Analogs. International Journal of Medicinal Chemistry No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-493379
American Medical Association (AMA)
Choudary, Jayant& Kini, Suvarna G.& Ranganath Pai Karkala, Sreedhara& Mubeen, Muhammad. Docking Studies and Biological Activity of Fosinopril Analogs. International Journal of Medicinal Chemistry. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-493379
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493379
