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Successful Hematopoietic Stem Cell Transplantation Following a Cyclophosphamide-Containing Preparative Regimen with Concomitant Phenobarbital Administration
Joint Authors
Copelan, Edward A.
Weber, Catherine
Kasberg, Heather
Source
Case Reports in Transplantation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-11
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Cyclophosphamide is an immunosuppressive agent and an anticancer prodrug which requires bioactivation catalyzed primarily by cytochrome P450 enzymes in order to be transformed into its active alkylating compounds.
Concomitant administration of drugs known to inhibit or induce this enzyme system is a clinical concern.
Herein, we present the case of a chronically ill 21-year-old patient who received high-dose cyclophosphamide, equine antithymocyte globulin (eATG), and total body irradiation (TBI) followed by an allogeneic hematopoietic stem cell transplant (HSCT) for severe aplastic anemia.
Throughout her hospitalization, she continued to receive quadruple anticonvulsant therapy including phenobarbital for her long-standing seizure history.
The preparative regimen was tolerated well aside from a hypersensitivity reaction to eATG, and minimal cyclophosphamide-related toxicities.
Safe and effective administration of high-dose cyclophosphamide was possible with multidisciplinary care consisting of physician, nursing, pharmacy, neurology consultation, as well as social work and case management.
American Psychological Association (APA)
Weber, Catherine& Kasberg, Heather& Copelan, Edward A.. 2012. Successful Hematopoietic Stem Cell Transplantation Following a Cyclophosphamide-Containing Preparative Regimen with Concomitant Phenobarbital Administration. Case Reports in Transplantation،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-493381
Modern Language Association (MLA)
Weber, Catherine…[et al.]. Successful Hematopoietic Stem Cell Transplantation Following a Cyclophosphamide-Containing Preparative Regimen with Concomitant Phenobarbital Administration. Case Reports in Transplantation No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-493381
American Medical Association (AMA)
Weber, Catherine& Kasberg, Heather& Copelan, Edward A.. Successful Hematopoietic Stem Cell Transplantation Following a Cyclophosphamide-Containing Preparative Regimen with Concomitant Phenobarbital Administration. Case Reports in Transplantation. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-493381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493381