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Methodology for Anti-Gene Anti-IGF-I Therapy of Malignant Tumours
Joint Authors
Ardourel, Marie-Yvonne
Briceno, Ignacio
Kasprzak, Heliodor
Ly, Adama
Wei, Ming X.
Andres, Christian
Aristizabal, Beatriz H.
Trojan, Ladislas A.
Bierwagen, Maciej
Pan, Yuexin X.
Anthony, Donald D.
Trojan, Jerzy
Noguera, Maria C.
Alvarez, Alvaro
Shevelev, Alexander
Duc, Huynh T.
Source
Chemotherapy Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of this study was to establish the criteria for methodology of cellular “anti-IGF-I” therapy of malignant tumours and particularly for glioblastoma multiforme.
The treatment of primary glioblastoma patients using surgery, radiotherapy, and chemotherapy was followed by subcutaneous injection of autologous cancer cells transfected by IGF-I antisense/triple helix expression vectors.
The prepared cell “vaccines” should it be in the case of glioblastomas or other tumours, have shown a change of phenotype, the absence of IGF-I protein, and expression of MHC-I and B7.
The peripheral blood lymphocytes, PBL cells, removed after each of two successive vaccinations, have demonstrated for all the types of tumour tested an increasing level of CD8+ and CD8+28+ molecules and a switch from CD8+11b+ to CD8+11.
All cancer patients were supervised for up to 19 months, the period corresponding to minimum survival of glioblastoma patients.
The obtained results have permitted to specify the common criteria for “anti-IGF-I” strategy: characteristics sine qua non of injected “vaccines” (cloned cells IGF-I(−) and MHC-I(+)) and of PBL cells (CD8+ increased level).Erratum to “Methodology for Anti-Gene Anti-IGF-I Therapy of Malignant Tumours”dx.doi.org/10.1155/2012/765703
American Psychological Association (APA)
Trojan, Jerzy& Pan, Yuexin X.& Wei, Ming X.& Ly, Adama& Shevelev, Alexander& Bierwagen, Maciej…[et al.]. 2012. Methodology for Anti-Gene Anti-IGF-I Therapy of Malignant Tumours. Chemotherapy Research and Practice،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-493387
Modern Language Association (MLA)
Trojan, Jerzy…[et al.]. Methodology for Anti-Gene Anti-IGF-I Therapy of Malignant Tumours. Chemotherapy Research and Practice No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-493387
American Medical Association (AMA)
Trojan, Jerzy& Pan, Yuexin X.& Wei, Ming X.& Ly, Adama& Shevelev, Alexander& Bierwagen, Maciej…[et al.]. Methodology for Anti-Gene Anti-IGF-I Therapy of Malignant Tumours. Chemotherapy Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-493387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493387