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Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury
Joint Authors
Aschner, Michael
Kaur, Parvinder
Syversen, Tore
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Methylmercury (MeHg), an environmental toxicant primarily found in fish and seafood, poses a dilemma to both consumers and regulatory authorities, given the nutritional benefits of fish consumption versus the possible adverse neurological damage.
Several studies have shown that MeHg toxicity is influenced by a number of biochemical factors, such as glutathione (GSH), fatty acids, vitamins, and essential elements, but the cellular mechanisms underlying these complex interactions have not yet been fully elucidated.
The objective of this paper is to outline the cellular response to dietary nutrients, as well as to describe the neurotoxic exposures to MeHg.
In order to determine the cellular mechanism(s) of toxicity, the effect of pretreatment with biochemical factors (e.g., N-acetyl cysteine, (NAC); diethyl maleate, (DEM); docosahexaenoic acid, (DHA); selenomethionine, SeM; Trolox) and MeHg treatment on intercellular antioxidant status, MeHg content, and other endpoints was evaluated.
This paper emphasizes that the protection against oxidative stress offered by these biochemical factors is among one of the major mechanisms responsible for conferring neuroprotection.
It is therefore critical to ascertain the cellular mechanisms associated with various dietary nutrients as well as to determine the potential effects of neurotoxic exposures for accurately assessing the risks and benefits associated with fish consumption.
American Psychological Association (APA)
Kaur, Parvinder& Aschner, Michael& Syversen, Tore. 2011. Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury. Journal of Toxicology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-493396
Modern Language Association (MLA)
Kaur, Parvinder…[et al.]. Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury. Journal of Toxicology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-493396
American Medical Association (AMA)
Kaur, Parvinder& Aschner, Michael& Syversen, Tore. Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury. Journal of Toxicology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-493396
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493396