Perspectives on Molecular Biomarkers of Oxidative Stress and Antioxidant Strategies in Traumatic Brain Injury
Joint Authors
Walz, Roger
Dafre, Alcir Luiz
Mendes Arent, André
Souza, Luiz Felipe de
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-13
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Traumatic brain injury (TBI) is frequently associated with abnormal blood-brain barrier function, resulting in the release of factors that can be used as molecular biomarkers of TBI, among them GFAP, UCH-L1, S100B, and NSE.
Although many experimental studies have been conducted, clinical consolidation of these biomarkers is still needed to increase the predictive power and reduce the poor outcome of TBI.
Interestingly, several of these TBI biomarkers are oxidatively modified to carbonyl groups, indicating that markers of oxidative stress could be of predictive value for the selection of therapeutic strategies.
Some drugs such as corticosteroids and progesterone have already been investigated in TBI neuroprotection but failed to demonstrate clinical applicability in advanced phases of the studies.
Dietary antioxidants, such as curcumin, resveratrol, and sulforaphane, have been shown to attenuate TBI-induced damage in preclinical studies.
These dietary antioxidants can increase antioxidant defenses via transcriptional activation of NRF2 and are also known as carbonyl scavengers, two potential mechanisms for neuroprotection.
This paper reviews the relevance of redox biology in TBI, highlighting perspectives for future studies.
American Psychological Association (APA)
Mendes Arent, André& Souza, Luiz Felipe de& Walz, Roger& Dafre, Alcir Luiz. 2014. Perspectives on Molecular Biomarkers of Oxidative Stress and Antioxidant Strategies in Traumatic Brain Injury. BioMed Research International،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-493403
Modern Language Association (MLA)
Mendes Arent, André…[et al.]. Perspectives on Molecular Biomarkers of Oxidative Stress and Antioxidant Strategies in Traumatic Brain Injury. BioMed Research International No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-493403
American Medical Association (AMA)
Mendes Arent, André& Souza, Luiz Felipe de& Walz, Roger& Dafre, Alcir Luiz. Perspectives on Molecular Biomarkers of Oxidative Stress and Antioxidant Strategies in Traumatic Brain Injury. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-493403
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493403