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Ginseng Is Useful to Enhance Cardiac Contractility in Animals
Joint Authors
Chang, Chen Kuei
Cherng, Yih-Giun
Niu, Chiang-Shan
Chen, Li-Jen
Niu, Ho-Shan
Lin, Jia-Wei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ginseng has been shown to be effective on cardiac dysfunction.
Recent evidence has highlighted the mediation of peroxisome proliferator-activated receptors (PPARs) in cardiac function.
Thus, we are interested to investigate the role of PPARδ in ginseng-induced modification of cardiac contractility.
The isolated hearts in Langendorff apparatus and hemodynamic analysis in catheterized rats were applied to measure the actions of ginseng ex vivo and in vivo.
In normal rats, ginseng enhanced cardiac contractility and hemodynamic dP/dtmax significantly.
Both actions were diminished by GSK0660 at a dose enough to block PPARδ.
However, ginseng failed to modify heart rate at the same dose, although it did produce a mild increase in blood pressure.
Data of intracellular calcium level and Western blotting analysis showed that both the PPARδ expression and troponin I phosphorylation were raised by ginseng in neonatal rat cardiomyocyte.
Thus, we suggest that ginseng could enhance cardiac contractility through increased PPARδ expression in cardiac cells.
American Psychological Association (APA)
Lin, Jia-Wei& Cherng, Yih-Giun& Chen, Li-Jen& Niu, Ho-Shan& Chang, Chen Kuei& Niu, Chiang-Shan. 2014. Ginseng Is Useful to Enhance Cardiac Contractility in Animals. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-493406
Modern Language Association (MLA)
Lin, Jia-Wei…[et al.]. Ginseng Is Useful to Enhance Cardiac Contractility in Animals. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-493406
American Medical Association (AMA)
Lin, Jia-Wei& Cherng, Yih-Giun& Chen, Li-Jen& Niu, Ho-Shan& Chang, Chen Kuei& Niu, Chiang-Shan. Ginseng Is Useful to Enhance Cardiac Contractility in Animals. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-493406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493406