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Efavirenz Conceptions and Regimen Management in a Prospective Cohort of Women on Antiretroviral Therapy
Joint Authors
Taha, Taha E.
Venter, Willem Daniel Francois
Black, Vivian
Mehta, Shruti
Schwartz, Sheree
Rees, Helen
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Use of the antiretroviral drug efavirenz (EFV) is not recommended by the WHO or South African HIV treatment guidelines during the first trimester of pregnancy due to potential fetal teratogenicity; there is little evidence of how clinicians manage EFV-related fertility concerns.
Women on antiretroviral therapy (ART) were enrolled into a prospective cohort in four public clinics in Johannesburg, South Africa.
Fertility intentions, ART regimens, and pregnancy testing were routinely assessed during visits.
Women reporting that they were trying to conceive while on EFV were referred for regimen changes.
Kaplan-Meier estimators were used to assess incidence across ART regimens.
From the 822 women with followup visits between August 2009–March 2011, 170 pregnancies were detected during study followup, including 56 EFV conceptions.
Pregnancy incidence rates were comparable across EFV, nevirapine, and lopinavir/ritonavir person-years (95% 100/users (P=0.25)); incidence rates on EFV were 18.6 Confidence Interval: 14.2–24.2).
Treatment substitution from EFV was made for 57 women, due to pregnancy intentions or actual pregnancy; however, regimen changes were not systematically applied across women.
High rates of pregnancy on EFV and inconsistencies in treatment management suggest that clearer guidelines are needed regarding how to manage fertility-related issues in.
women on EFV-based regimens.
American Psychological Association (APA)
Schwartz, Sheree& Taha, Taha E.& Venter, Willem Daniel Francois& Mehta, Shruti& Rees, Helen& Black, Vivian. 2012. Efavirenz Conceptions and Regimen Management in a Prospective Cohort of Women on Antiretroviral Therapy. Infectious Diseases in Obstetrics and Gynecology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-493408
Modern Language Association (MLA)
Schwartz, Sheree…[et al.]. Efavirenz Conceptions and Regimen Management in a Prospective Cohort of Women on Antiretroviral Therapy. Infectious Diseases in Obstetrics and Gynecology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-493408
American Medical Association (AMA)
Schwartz, Sheree& Taha, Taha E.& Venter, Willem Daniel Francois& Mehta, Shruti& Rees, Helen& Black, Vivian. Efavirenz Conceptions and Regimen Management in a Prospective Cohort of Women on Antiretroviral Therapy. Infectious Diseases in Obstetrics and Gynecology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-493408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493408