GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia
Joint Authors
Gonzalez-Burgos, Guillermo
Lewis, David A.
Fish, Kenneth N.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-05
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
Schizophrenia is a brain disorder associated with cognitive deficits that severely affect the patients' capacity for daily functioning.
Whereas our understanding of its pathophysiology is limited, postmortem studies suggest that schizophrenia is associated with deficits of GABA-mediated synaptic transmission.
A major role of GABA-mediated transmission may be producing synchronized network oscillations which are currently hypothesized to be essential for normal cognitive function.
Therefore, cognitive deficits in schizophrenia may result from a GABA synapse dysfunction that disturbs neural synchrony.
Here, we highlight recent studies further suggesting alterations of GABA transmission and network oscillations in schizophrenia.
We also review current models for the mechanisms of GABA-mediated synchronization of neural activity, focusing on parvalbumin-positive GABA neurons, which are altered in schizophrenia and whose function has been strongly linked to the production of neural synchrony.
Alterations of GABA signaling that impair gamma oscillations and, as a result, cognitive function suggest paths for novel therapeutic interventions.
American Psychological Association (APA)
Gonzalez-Burgos, Guillermo& Fish, Kenneth N.& Lewis, David A.. 2011. GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia. Neural Plasticity،Vol. 2011, no. 2011, pp.1-24.
https://search.emarefa.net/detail/BIM-493421
Modern Language Association (MLA)
Gonzalez-Burgos, Guillermo…[et al.]. GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia. Neural Plasticity No. 2011 (2011), pp.1-24.
https://search.emarefa.net/detail/BIM-493421
American Medical Association (AMA)
Gonzalez-Burgos, Guillermo& Fish, Kenneth N.& Lewis, David A.. GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia. Neural Plasticity. 2011. Vol. 2011, no. 2011, pp.1-24.
https://search.emarefa.net/detail/BIM-493421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493421