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Molecular Image Analysis : Quantitative Description and Classification of the Nuclear Lamina in Human Mesenchymal Stem Cells
Joint Authors
Righolt, Christiaan H.
Young, Ian T.
Raz, Vered
Dirks, Roeland W.
Vermolen, Bart J.
Tanke, Hans J.
Source
International Journal of Molecular Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The nuclear lamina is an intermediate filament network that provides a structural framework for the cell nucleus.
Changes in lamina structure are found during changes in cell fate such as cell division or cell death and are associated with human diseases.
An unbiased method that quantifies changes in lamina shape can provide information on cells undergoing changes in cellular functions.
We have developed an image processing methodology that finds and quantifies the 3D structure of the nuclear lamina.
We show that measurements on such images can be used for cell classification and provide information concerning protein spatial localization in this structure.
To demonstrate the efficacy of this method, we compared the lamina of unmanipulated human mesenchymal stem cells (hMSCs) at passage 4 to cells activated for apoptosis.
A statistically significant classification was found between the two populations.
American Psychological Association (APA)
Righolt, Christiaan H.& Raz, Vered& Vermolen, Bart J.& Dirks, Roeland W.& Tanke, Hans J.& Young, Ian T.. 2010. Molecular Image Analysis : Quantitative Description and Classification of the Nuclear Lamina in Human Mesenchymal Stem Cells. International Journal of Molecular Imaging،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-493427
Modern Language Association (MLA)
Righolt, Christiaan H.…[et al.]. Molecular Image Analysis : Quantitative Description and Classification of the Nuclear Lamina in Human Mesenchymal Stem Cells. International Journal of Molecular Imaging No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-493427
American Medical Association (AMA)
Righolt, Christiaan H.& Raz, Vered& Vermolen, Bart J.& Dirks, Roeland W.& Tanke, Hans J.& Young, Ian T.. Molecular Image Analysis : Quantitative Description and Classification of the Nuclear Lamina in Human Mesenchymal Stem Cells. International Journal of Molecular Imaging. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-493427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493427