![](/images/graphics-bg.png)
Prostaglandins in Cancer Cell Adhesion, Migration, and Invasion
Joint Authors
Menter, David G.
DuBois, Raymond N.
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-29
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Prostaglandins exert a profound influence over the adhesive, migratory, and invasive behavior of cells during the development and progression of cancer.
Cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) are upregulated in inflammation and cancer.
This results in the production of prostaglandin E2 (PGE2), which binds to and activates G-protein-coupled prostaglandin E1–4 receptors (EP1–4).
Selectively targeting the COX-2/mPGES-1/PGE2/EP1–4 axis of the prostaglandin pathway can reduce the adhesion, migration, invasion, and angiogenesis.
Once stimulated by prostaglandins, cadherin adhesive connections between epithelial or endothelial cells are lost.
This enables cells to invade through the underlying basement membrane and extracellular matrix (ECM).
Interactions with the ECM are mediated by cell surface integrins by “outside-in signaling” through Src and focal adhesion kinase (FAK) and/or “inside-out signaling” through talins and kindlins.
Combining the use of COX-2/mPGES-1/PGE2/EP1–4 axis-targeted molecules with those targeting cell surface adhesion receptors or their downstream signaling molecules may enhance cancer therapy.
American Psychological Association (APA)
Menter, David G.& DuBois, Raymond N.. 2012. Prostaglandins in Cancer Cell Adhesion, Migration, and Invasion. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-493434
Modern Language Association (MLA)
Menter, David G.& DuBois, Raymond N.. Prostaglandins in Cancer Cell Adhesion, Migration, and Invasion. International Journal of Cell Biology No. 2012 (2012), pp.1-21.
https://search.emarefa.net/detail/BIM-493434
American Medical Association (AMA)
Menter, David G.& DuBois, Raymond N.. Prostaglandins in Cancer Cell Adhesion, Migration, and Invasion. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-493434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493434