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Sickling Cells, Cyclic Nucleotides, and Protein Kinases : The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia
Joint Authors
Claudino, Mário Angelo
Fertrin, Kleber Yotsumoto
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Sickle cell anemia is one of the best studied inherited diseases, and despite being caused by a single point mutation in the HBB gene, multiple pleiotropic effects of the abnormal hemoglobin S production range from vaso-occlusive crisis, stroke, and pulmonary hypertension to osteonecrosis and leg ulcers.
Urogenital function is not spared, and although priapism is most frequently remembered, other related clinical manifestations have been described, such as nocturia, enuresis, increased frequence of lower urinary tract infections, urinary incontinence, hypogonadism, and testicular infarction.
Studies on sickle cell vaso-occlusion and priapism using both in vitro and in vivo models have shed light on the pathogenesis of some of these events.
The authors review what is known about the deleterious effects of sickling on the genitourinary tract and how the role of cyclic nucleotides signaling and protein kinases may help understand the pathophysiology underlying these manifestations and develop novel therapies in the setting of urogenital disorders in sickle cell disease.
American Psychological Association (APA)
Claudino, Mário Angelo& Fertrin, Kleber Yotsumoto. 2012. Sickling Cells, Cyclic Nucleotides, and Protein Kinases : The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia. Anemia،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-493446
Modern Language Association (MLA)
Claudino, Mário Angelo& Fertrin, Kleber Yotsumoto. Sickling Cells, Cyclic Nucleotides, and Protein Kinases : The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia. Anemia No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-493446
American Medical Association (AMA)
Claudino, Mário Angelo& Fertrin, Kleber Yotsumoto. Sickling Cells, Cyclic Nucleotides, and Protein Kinases : The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia. Anemia. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-493446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493446