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Neuron Loss in Transgenic Mouse Models of Alzheimer's Disease
Joint Authors
Bayer, Thomas A.
Wirths, Oliver
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Since their initial generation in the mid 1990s, transgenic mouse models of Alzheimers's disease (AD) have been proven to be valuable model systems which are indispensable for modern AD research.
Whereas most of these models are characterized by extensive amyloid plaque pathology, inflammatory changes and often behavioral deficits, modeling of neuron loss was much less successful.
The present paper discusses the current achievements of modeling neuron loss in transgenic mouse models based on APP/Aβ and Tau overexpression and provides an overview of currently available AD mouse models showing these pathological alterations.
American Psychological Association (APA)
Wirths, Oliver& Bayer, Thomas A.. 2010. Neuron Loss in Transgenic Mouse Models of Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-493473
Modern Language Association (MLA)
Wirths, Oliver& Bayer, Thomas A.. Neuron Loss in Transgenic Mouse Models of Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-493473
American Medical Association (AMA)
Wirths, Oliver& Bayer, Thomas A.. Neuron Loss in Transgenic Mouse Models of Alzheimer's Disease. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-493473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493473