Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2)‎ and Phosphotyrosine Phosphatase SHP-1 (PTPN6)‎ According to Tumor Progression

Joint Authors

Rojas, María Eugenia
Rodríguez, Dora Isabel
Cubilla, Marisa Angelica
Zapata, Pedro Darío
Tiscornia, María Mercedes
Riera, Mario Alejandro
Chaneton, Bárbara Julieta
Giorgio, Ernesto Martín
Gimenez, Esteban Mariano
Cariaga-Martinez, Ariel Ernesto
Lorenzati, María Angelica
De La Rossa, Andrés

Source

Advances in Urology

Issue

Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2009-04-12

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases

Abstract EN

Prostate proliferation is dependent of androgens and many peptide hormones.

Recent reports suggest that SSTR2 and SHP-1 were two fundamental components on antiproliferative effect of somatostatin.

Many studies on SHP-1 revealed that the expression of this protein was diminished or abolished in several of the cancer cell lines and tissues examined.

However, it is necessary to confront the cell lines data with real situation in cancer cases.

Our studies have shown that epithelial expressions of both proteins, SHP-1 and SSTR2, in normal and benign hyperplasia are localized in the luminal side of duct and acinar cells.

Also, SSTR2 is expressed in stromal cells.

In malignant prostate tissue, SHP-1 was diminished in 28/45 cases or absent in 12/45 cases, whereas SSTR2 epithelial was diminished in 38/45 cases or lost in only 2/45 cases.

The intensity of immunostained was highly negative correlated with Gleason grade for two proteins.

American Psychological Association (APA)

Cariaga-Martinez, Ariel Ernesto& Lorenzati, María Angelica& Riera, Mario Alejandro& Cubilla, Marisa Angelica& De La Rossa, Andrés& Giorgio, Ernesto Martín…[et al.]. 2009. Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression. Advances in Urology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-493479

Modern Language Association (MLA)

Cariaga-Martinez, Ariel Ernesto…[et al.]. Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression. Advances in Urology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-493479

American Medical Association (AMA)

Cariaga-Martinez, Ariel Ernesto& Lorenzati, María Angelica& Riera, Mario Alejandro& Cubilla, Marisa Angelica& De La Rossa, Andrés& Giorgio, Ernesto Martín…[et al.]. Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression. Advances in Urology. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-493479

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-493479