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A Rat Model of Thrombosis in Common Carotid Artery Induced by Implantable Wireless Light-Emitting Diode Device
Joint Authors
Hsiao, Yung-Chin
Lee, Tsong-Hai
Lou, Shyh-Liang
Huang, Kuo-Lun
Lin, Yun-Han
Yeh, Jih-Chao
Hsu, Yu-Han
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This work has developed a novel approach to form common carotid artery (CCA) thrombus in rats with a wireless implantable light-emitting diode (LED) device.
The device mainly consists of an external controller and an internal LED assembly.
The controller was responsible for wirelessly transmitting electrical power.
The internal LED assembly served as an implant to receive the power and irradiate light on CCA.
The thrombus formation was identified with animal sonography, 7T magnetic resonance imaging, and histopathologic examination.
The present study showed that a LED assembly implanted on the outer surface of CCA could induce acute occlusion with single irradiation with 6 mW/cm2 LED for 4 h.
If intermittent irradiation with 4.3–4.5 mW/cm2 LED for 2 h was shut off for 30 min, then irradiation for another 2 h was applied; the thrombus was observed to grow gradually and was totally occluded at 7 days.
Compared with the contralateral CCA without LED irradiation, the arterial endothelium in the LED-irradiated artery was discontinued.
Our study has shown that, by adjusting the duration of irradiation and the power intensity of LED, it is possible to produce acute occlusion and progressive thrombosis, which can be used as an animal model for antithrombotic drug development.
American Psychological Association (APA)
Yeh, Jih-Chao& Huang, Kuo-Lun& Hsiao, Yung-Chin& Hsu, Yu-Han& Lin, Yun-Han& Lou, Shyh-Liang…[et al.]. 2014. A Rat Model of Thrombosis in Common Carotid Artery Induced by Implantable Wireless Light-Emitting Diode Device. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-493514
Modern Language Association (MLA)
Yeh, Jih-Chao…[et al.]. A Rat Model of Thrombosis in Common Carotid Artery Induced by Implantable Wireless Light-Emitting Diode Device. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-493514
American Medical Association (AMA)
Yeh, Jih-Chao& Huang, Kuo-Lun& Hsiao, Yung-Chin& Hsu, Yu-Han& Lin, Yun-Han& Lou, Shyh-Liang…[et al.]. A Rat Model of Thrombosis in Common Carotid Artery Induced by Implantable Wireless Light-Emitting Diode Device. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-493514
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493514