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The Clinicopathological Significance of MicroRNA-155 in Breast Cancer : A Meta-Analysis
Joint Authors
Long, Xinghua
Cai, Qing
Zeng, Hui
Fang, Cheng
Nam, Seungyoon
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Previous studies demonstrated that the associations between expression level of microRNA-155 (miR-155) and clinicopathological significance of breast cancer remained inconsistent.
Therefore, we performed a meta-analysis based on eligible studies to summarize the possible associations.
Methods.
We identified eligible studies published up to May 2014 by a comprehensive search of PubMed, EMBASE, CNKI, and VIP databases.
The analysis was performed with RevMan.
5.0 software.
Results.
A total of 15 studies were included.
The results of meta-analysis showed that miR-155 was positively correlated with breast cancer with standardized mean difference (SMD) = 1.22.
Elevated miR-155 was found in Her-2 positive or lymph node metastasis positive, or p53 mutant type breast cancer.
But the result showed to be insignificant in TNM comparison.
With respect to estrogen receptor alpha (ER) and progesterone receptor (PR) status, both of them showed significant associations with SMD = −1.2 and −1.85, respectively.
Conclusion.
MiR-155 detection might have a diagnostic value in breast cancer patients.
It might be used as an auxiliary biomarker for different clinicopathological breast cancer.
American Psychological Association (APA)
Zeng, Hui& Fang, Cheng& Nam, Seungyoon& Cai, Qing& Long, Xinghua. 2014. The Clinicopathological Significance of MicroRNA-155 in Breast Cancer : A Meta-Analysis. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-493524
Modern Language Association (MLA)
Zeng, Hui…[et al.]. The Clinicopathological Significance of MicroRNA-155 in Breast Cancer : A Meta-Analysis. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-493524
American Medical Association (AMA)
Zeng, Hui& Fang, Cheng& Nam, Seungyoon& Cai, Qing& Long, Xinghua. The Clinicopathological Significance of MicroRNA-155 in Breast Cancer : A Meta-Analysis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-493524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493524