A Novel Use of Early Radiation Therapy in the Treatment of Hyperbilirubinemia in a Patient with Primary Hepatic Lymphoma and Chronic Hepatitis C
Joint Authors
Begum, Rehana
Tammana, Venkata S.
Muley, Amruta
Karpurapu, Hemamalini
Hasan, Nabhani
Dunmore-Griffith, Jacquelyn
Mekonen, Eyasu
Yeruva, Sri Lakshmi Hyndavi
Oneal, Patricia
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Lymphomas arising in the liver are extremely rare.
Here, we describe a case of Hepatitis C virus infection with primary hepatic lymphoma (PHL) presenting with hyperbilirubinemia.
A 45-year-old African American male presented with abdominal pain, pruritus, and itching for two days.
CT of abdomen and pelvis with contrast showed numerous masses in the liver.
The liver biopsy was consistent with diffuse large B cell lymphoma (DLBCL).
Conventional chemotherapy was avoided initially because of hyperbilirubinemia.
Hence, radiation therapy was given initially to reduce his bilirubin levels and tumor size.
The patient was able to complete six cycles of rituximab combined with cyclophosphamide, adriamycin, vincristine, and prednisone (R-CHOP) chemotherapy and achieved a complete response verified by positron emission tomography-computed tomography (PET-CT).
PHL should be considered when there are numerous space occupying liver lesions seen on imaging.
Hyperbilirubinemia may be a reason for delay in treatment for some of these patients.
Hence, the role of radiation therapy prior to treatment with R-CHOP is an alternative to management for stage IV diffuse large B cell lymphoma.
American Psychological Association (APA)
Tammana, Venkata S.& Begum, Rehana& Oneal, Patricia& Karpurapu, Hemamalini& Muley, Amruta& Yeruva, Sri Lakshmi Hyndavi…[et al.]. 2014. A Novel Use of Early Radiation Therapy in the Treatment of Hyperbilirubinemia in a Patient with Primary Hepatic Lymphoma and Chronic Hepatitis C. Case Reports in Gastrointestinal Medicine،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-493531
Modern Language Association (MLA)
Tammana, Venkata S.…[et al.]. A Novel Use of Early Radiation Therapy in the Treatment of Hyperbilirubinemia in a Patient with Primary Hepatic Lymphoma and Chronic Hepatitis C. Case Reports in Gastrointestinal Medicine No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-493531
American Medical Association (AMA)
Tammana, Venkata S.& Begum, Rehana& Oneal, Patricia& Karpurapu, Hemamalini& Muley, Amruta& Yeruva, Sri Lakshmi Hyndavi…[et al.]. A Novel Use of Early Radiation Therapy in the Treatment of Hyperbilirubinemia in a Patient with Primary Hepatic Lymphoma and Chronic Hepatitis C. Case Reports in Gastrointestinal Medicine. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-493531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493531