Treatment of Idiopathic Parkinson's Disease with Traditional Chinese Herbal Medicine : A Randomized Placebo-Controlled Pilot Clinical Study
Joint Authors
Li, Min
Lu, Jia Hong
Lam, Yuen Chi
Man, Sui Cheung
Huang, Xian Zhang
Xie, Li Xia
Wang, Yan
Kum, Wan Fung
Bian, Zhao Xiang
Durairajan, Siva Sundara Kumar
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The objective of this clinical study is to examine the effects of a Chinese herbal medicine formula (Jia Wei Liu Jun Zi Tang: JWLJZT) on motor and non-motor symptoms, and on complications of conventional therapy in idiopathic Parkinson's disease (PD), using an add-on design.
Fifty-five patients with PD were randomly allocated to receive either Chinese herbal medicine or placebo for 24 weeks.
Primary outcome measure was the 39-item Parkinson's Disease Questionnaire (PDQ-39).
Secondary outcome measures included the Unified Parkinson's Disease Rating Scale (UPDRS), Short-Form-36 Health Survey (SF-36), Geriatric Depression Scale (GDS), home diaries, and a range of category rating scales.
JWLJZT resulted in a significant improvement in the UPDRS IVC when compared with placebo at 12 weeks (P = .039) and 24 weeks (P = .034).
In addition, patients in the Chinese herbal medicine group also showed significant improvement in PDQ-39 communication scores at 12 weeks (P = .024) and 24 weeks (P = .047) when compared with the placebo group.
There were no significant differences between treatment and control groups for SF-36 variables, GDS score or the mean daily “on-off” time.
One case of mild diarrhea was noted in the treatment group.
The findings suggest that JWLJZT can relieve some non-motor complications of conventional therapy and improve the communication ability in patients with PD.
The results of this pilot study warrant larger multi-center clinical studies to assess long-term efficacy and tolerability of JWLJZT, and to elucidate the mechanisms by which it affects PD function.
American Psychological Association (APA)
Kum, Wan Fung& Durairajan, Siva Sundara Kumar& Bian, Zhao Xiang& Man, Sui Cheung& Lam, Yuen Chi& Xie, Li Xia…[et al.]. 2011. Treatment of Idiopathic Parkinson's Disease with Traditional Chinese Herbal Medicine : A Randomized Placebo-Controlled Pilot Clinical Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-493540
Modern Language Association (MLA)
Kum, Wan Fung…[et al.]. Treatment of Idiopathic Parkinson's Disease with Traditional Chinese Herbal Medicine : A Randomized Placebo-Controlled Pilot Clinical Study. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-493540
American Medical Association (AMA)
Kum, Wan Fung& Durairajan, Siva Sundara Kumar& Bian, Zhao Xiang& Man, Sui Cheung& Lam, Yuen Chi& Xie, Li Xia…[et al.]. Treatment of Idiopathic Parkinson's Disease with Traditional Chinese Herbal Medicine : A Randomized Placebo-Controlled Pilot Clinical Study. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-493540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493540