Emerging Therapeutic Strategies for Targeting Chronic Myeloid Leukemia Stem Cells
Joint Authors
Sahli, Zeyad
Nasr, Rihab
Hamad, Ahmad
Mouteirik, Maha
El Sabban, Maya
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder.
Current targeted therapies designed to inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein have made a significant breakthrough in the treatment of CML patients.
However, CML remains a chronic disease that a patient must manage for life.
Although tyrosine kinase inhibitors (TKI) therapy has completely transformed the prognosis of CML, it has made the therapeutic management more complex.
The interruption of TKI treatment results in early disease progression because it does not eliminate quiescent CML stem cells which remain a potential reservoir for disease relapse.
This highlights the need to develop new therapeutic strategies for CML to achieve a permanent cure, and to allow TKI interruption.
This review summarizes recent research done on alternative targeted therapies with a particular focus on some important signaling pathways (such as Alox5, Hedgehog, Wnt/b-catenin, autophagy, and PML) that have the potential to target CML stem cells and potentially provide cure for CML.
American Psychological Association (APA)
Hamad, Ahmad& Sahli, Zeyad& El Sabban, Maya& Mouteirik, Maha& Nasr, Rihab. 2013. Emerging Therapeutic Strategies for Targeting Chronic Myeloid Leukemia Stem Cells. Stem Cells International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-493541
Modern Language Association (MLA)
Hamad, Ahmad…[et al.]. Emerging Therapeutic Strategies for Targeting Chronic Myeloid Leukemia Stem Cells. Stem Cells International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-493541
American Medical Association (AMA)
Hamad, Ahmad& Sahli, Zeyad& El Sabban, Maya& Mouteirik, Maha& Nasr, Rihab. Emerging Therapeutic Strategies for Targeting Chronic Myeloid Leukemia Stem Cells. Stem Cells International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-493541
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493541