The Association of IL-12b Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population
Joint Authors
Zhang, Wei
Zhang, Jie
Wan, Jun
Shao, Yong
Chen, Yuewen
Yu, Bo
Wu, Qi
Guan, Ming
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Systemic lupus erythematosus (SLE) is a complex immune disease.
The genetic variation in the IL-12b gene was found to associate with SLE in Caucasian population.
In this study, we examined this association in Chinese Han population by a recently developed method, unlabeled probe-based high resolution melting analysis.
Methods.
A total of 297 SLE patients and 351 controls were recruited.
Unlabeled probe-based high resolution melting analysis (HRMA) was used in genotyping.
Results.
Statistically significant differences were observed in both genotype and allele frequencies for rs6887695 in the SLE patients as compared with the controls.
Minor allele (C) of rs6887695 (P=0.031, OR 0.78, [95% CI 0.63-0.98]) was found to be protective against SLE.
The association of SNP rs6887695 with the diagnostic criteria of SLE was also examined.
Minor allele (C) exerts protective effect on the incidence of arthritis (P=0.013, OR = 0.65, 95% CI = 0.47-0.92) and abnormalities of antinuclear antibody (P=0.022, OR = 0.68, 95% CI = 0.49–0.95).
IL-12b SNPs were irrelevant to other diagnostic criteria of SLE.
Summary.
Polymorphisms of rs6887695 in IL-12b gene were associated with disease risk, as well as arthritis and antinuclear antibody synthesis, of systemic lupus erythematosus in Chinese population.
American Psychological Association (APA)
Shao, Yong& Zhang, Jie& Chen, Yuewen& Wu, Qi& Guan, Ming& Yu, Bo…[et al.]. 2012. The Association of IL-12b Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-493581
Modern Language Association (MLA)
Shao, Yong…[et al.]. The Association of IL-12b Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population. International Journal of Rheumatology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-493581
American Medical Association (AMA)
Shao, Yong& Zhang, Jie& Chen, Yuewen& Wu, Qi& Guan, Ming& Yu, Bo…[et al.]. The Association of IL-12b Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-493581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493581