Oxidative Stress and Down Syndrome : A Route toward Alzheimer-Like Dementia

Joint Authors

Perluigi, Marzia
Butterfield, D. Allan

Source

Current Gerontology and Geriatrics Research

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-11-29

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases

Abstract EN

Down syndrome (DS) is one of the most frequent genetic abnormalities characterized by multiple pathological phenotypes.

Indeed, currently life expectancy and quality of life for DS patients have improved, although with increasing age pathological dysfunctions are exacerbated and intellectual disability may lead to the development of Alzheimer's type dementia (AD).

The neuropathology of DS is complex and includes the development of AD by middle age, altered free radical metabolism, and impaired mitochondrial function, both of which contribute to neuronal degeneration.

Understanding the molecular basis that drives the development of AD is an intense field of research.

Our laboratories are interested in understanding the role of oxidative stress as link between DS and AD.

This review examines the current literature that showed oxidative damage in DS by identifying putative molecular pathways that play a central role in the neurodegenerative processes.

In addition, considering the role of mitochondrial dysfunction in neurodegenerative phenomena, results demonstrating the involvement of impaired mitochondria in DS pathology could contribute a direct link between normal aging and development of AD-like dementia in DS patients.

American Psychological Association (APA)

Perluigi, Marzia& Butterfield, D. Allan. 2011. Oxidative Stress and Down Syndrome : A Route toward Alzheimer-Like Dementia. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-493585

Modern Language Association (MLA)

Perluigi, Marzia& Butterfield, D. Allan. Oxidative Stress and Down Syndrome : A Route toward Alzheimer-Like Dementia. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-493585

American Medical Association (AMA)

Perluigi, Marzia& Butterfield, D. Allan. Oxidative Stress and Down Syndrome : A Route toward Alzheimer-Like Dementia. Current Gerontology and Geriatrics Research. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-493585

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-493585