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Cost Effectiveness of First-Line Treatment with DoxorubicinIfosfamide Compared to Trabectedin Monotherapy in the Management of Advanced Soft Tissue Sarcoma in Italy, Spain, and Sweden
Joint Authors
Panca, Monica
Linch, Mark
Guest, Julian F.
Sladkevicius, Erikas
Gough, Nicholas J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-03
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Background.
Doxorubicin/ifosfamide is a first-line systemic chemotherapy for the majority of advanced soft tissue sarcoma (ASTS) subtypes.
Trabectedin is indicated for the treatment of ASTS after failure of anthracyclines and/or ifosfamide; however it is being increasingly used off-label as a first-line treatment.
This study estimated the cost effectiveness of these two treatments in the first-line management of ASTS in Italy, Spain, and Sweden.
Methods.
A Markov model was constructed to estimate the cost effectiveness of doxorubicin/ifosfamide compared to trabectedin monotherapy, defined as the cost per QALY gained, in each country.
Results.
First-line treatment with doxorubicin/ifosfamide resulted in lower two-year healthcare costs and more QALYs than first-line treatment with trabectedin monotherapy in all three countries.
Probabilistic sensitivity analysis showed that at a cost per QALY threshold of €35,000, >90% of a cohort would be cost effectively treated with doxorubicin/ifosfamide compared to trabectedin monotherapy in all three countries.
Conclusion.
Within the model’s limitations, first-line treatment of patients with ASTS with doxorubicin/ifosfamide instead of trabectedin monotherapy affords a cost-effective use of publicly funded healthcare resources in Italy, Spain, and Sweden and is therefore the preferred treatment in all three countries.
These findings support the recommendation that trabectedin should remain a second-line treatment.
American Psychological Association (APA)
Guest, Julian F.& Panca, Monica& Sladkevicius, Erikas& Gough, Nicholas J.& Linch, Mark. 2013. Cost Effectiveness of First-Line Treatment with DoxorubicinIfosfamide Compared to Trabectedin Monotherapy in the Management of Advanced Soft Tissue Sarcoma in Italy, Spain, and Sweden. Sarcoma،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-493633
Modern Language Association (MLA)
Guest, Julian F.…[et al.]. Cost Effectiveness of First-Line Treatment with DoxorubicinIfosfamide Compared to Trabectedin Monotherapy in the Management of Advanced Soft Tissue Sarcoma in Italy, Spain, and Sweden. Sarcoma No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-493633
American Medical Association (AMA)
Guest, Julian F.& Panca, Monica& Sladkevicius, Erikas& Gough, Nicholas J.& Linch, Mark. Cost Effectiveness of First-Line Treatment with DoxorubicinIfosfamide Compared to Trabectedin Monotherapy in the Management of Advanced Soft Tissue Sarcoma in Italy, Spain, and Sweden. Sarcoma. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-493633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493633