Omega-3 Polyunsaturated Fatty Acids (n-3 PUFAs) in Cardiovascular Diseases (CVDs) and Depression : The Missing Link?
Joint Authors
Chang, Jane Pei-Chen
Su, Kuan-Pin
Chen, Yi-Ting
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Based on epidemiological data, clinical trials, and meta-analytic reviews, omega-3 polyunsaturated fatty acids (n-3 PUFAs) seem to be a biological link between depression and cardiovascular diseases (CVDs).
Presentation.
Involvement of n-3 PUFAs in depression and CVDs may be associated with a chronic, low-grade, inflammation.
We hypothesize that n-3 PUFAs link depression and CVDs via “PUFA-prostaglandin E2 (PGE2) cascade.” Testing.
To further support our hypothesis, case-control studies are needed to test the role of COX2 and PLA2 functions in depression and in CVDs.
In addition, the effects of n-3 PUFAs on cardiovascular markers in depression and on depressive symptoms in CVDs should be investigated in clinical trials.
Finally, the effects of manipulating COX2 and PLA2 functions on depression-like behaviors and cardiovascular functions could be explored in animal studies.
Implications.
n-3 PUFAs might be a promising treatment for both cardiovascular diseases and depression via its anti-inflammatory, cardioprotective, and neuroprotective effects.
American Psychological Association (APA)
Chang, Jane Pei-Chen& Chen, Yi-Ting& Su, Kuan-Pin. 2009. Omega-3 Polyunsaturated Fatty Acids (n-3 PUFAs) in Cardiovascular Diseases (CVDs) and Depression : The Missing Link?. Cardiovascular Psychiatry and Neurology،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-493634
Modern Language Association (MLA)
Chang, Jane Pei-Chen…[et al.]. Omega-3 Polyunsaturated Fatty Acids (n-3 PUFAs) in Cardiovascular Diseases (CVDs) and Depression : The Missing Link?. Cardiovascular Psychiatry and Neurology No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-493634
American Medical Association (AMA)
Chang, Jane Pei-Chen& Chen, Yi-Ting& Su, Kuan-Pin. Omega-3 Polyunsaturated Fatty Acids (n-3 PUFAs) in Cardiovascular Diseases (CVDs) and Depression : The Missing Link?. Cardiovascular Psychiatry and Neurology. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-493634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493634