A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus Septicemia
Joint Authors
Sampson, Jacquelyn S.
Ades, Edwin W.
Rajam, Gowrisankar
Hammons, Gabrielle M.
Carlone, George M.
Source
International Journal of Microbiology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Staphylococcus aureus (SA) is a major community-acquired pathogen.
The emergence of drug-resistant strains like, methicillin-resistant SA (MRSA), poses stiff challenges to therapeutic intervention.
Passive immune-therapy with specific antibodies is being actively examined to treat fulminant infections with limited success.
In this study, we demonstrate that P4, a 28-amino acid peptide, derived from pneumococcal surface adhesin A along with pathogen-specific antibody (IVIG; P4 therapy) is successful in enhancing the opsonophagocytic killing (OPK) of S.
aureus in vitro.
We questioned if it is possible to expand P4 therapy to treat staphylococcal infections in vivo.
P4 therapy in combination with IVIG rescued 7/10 morbidly ill S.
aureus-infected mice while only 2/10 survived in the control group.
American Psychological Association (APA)
Rajam, Gowrisankar& Hammons, Gabrielle M.& Carlone, George M.& Sampson, Jacquelyn S.& Ades, Edwin W.. 2011. A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus Septicemia. International Journal of Microbiology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-493660
Modern Language Association (MLA)
Rajam, Gowrisankar…[et al.]. A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus Septicemia. International Journal of Microbiology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-493660
American Medical Association (AMA)
Rajam, Gowrisankar& Hammons, Gabrielle M.& Carlone, George M.& Sampson, Jacquelyn S.& Ades, Edwin W.. A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus Septicemia. International Journal of Microbiology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-493660
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493660
