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Friedreich's Ataxia, Frataxin, PIP5K1B : Echo of a Distant Fracas
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
“Frataxin fracas” were the words used when referring to the frataxin-encoding gene (FXN) burst in as a motive to disqualify an alternative candidate gene, PIP5K1B, as an actor in Friedreich's ataxia (FRDA) (Campuzano et al., 1996; Cossee et al., 1997; Carvajal et al., 1996).
The instrumental role in the disease of large triplet expansions in the first intron of FXN has been thereafter fully confirmed, and this no longer suffers any dispute (Koeppen, 2011).
On the other hand, a recent study suggests that the consequences of these large expansions in FXN are wider than previously thought and that the expression of surrounding genes, including PIP5K1B, could be concurrently modulated by these large expansions (Bayot et al., 2013).
This recent observation raises a number of important and yet unanswered questions for scientists and clinicians working on FRDA; these questions are the substratum of this paper.
American Psychological Association (APA)
Bayot, Aurélien& Rustin, Pierre. 2013. Friedreich's Ataxia, Frataxin, PIP5K1B : Echo of a Distant Fracas. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-493671
Modern Language Association (MLA)
Bayot, Aurélien& Rustin, Pierre. Friedreich's Ataxia, Frataxin, PIP5K1B : Echo of a Distant Fracas. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-493671
American Medical Association (AMA)
Bayot, Aurélien& Rustin, Pierre. Friedreich's Ataxia, Frataxin, PIP5K1B : Echo of a Distant Fracas. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-493671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493671