Stem Cell Niches in Glioblastoma : A Neuropathological View
Joint Authors
Piazzi, Angela
Caldera, Valentina
Schiffer, Davide
Melcarne, Antonio
Mellai, Marta
Denysenko, Tetyana
Annovazzi, Laura
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Glioblastoma (GBM) stem cells (GSCs), responsible for tumor growth, recurrence, and resistance to therapies, are considered the real therapeutic target, if they had no molecular mechanisms of resistance, in comparison with the mass of more differentiated cells which are insensitive to therapies just because of being differentiated and nonproliferating.
GSCs occur in tumor niches where both stemness status and angiogenesis are conditioned by the microenvironment.
In both perivascular and perinecrotic niches, hypoxia plays a fundamental role.
Fifteen glioblastomas have been studied by immunohistochemistry and immunofluorescence for stemness and differentiation antigens.
It has been found that circumscribed necroses develop inside hyperproliferating areas that are characterized by high expression of stemness antigens.
Necrosis developed inside them because of the imbalance between the proliferation of tumor cells and endothelial cells; it reduces the number of GSCs to a thin ring around the former hyperproliferating area.
The perinecrotic GSCs are nothing else that the survivors remnants of those populating hyperproliferating areas.
In the tumor, GSCs coincide with malignant areas so that the need to detect where they are located is not so urgent.
American Psychological Association (APA)
Schiffer, Davide& Mellai, Marta& Annovazzi, Laura& Caldera, Valentina& Piazzi, Angela& Denysenko, Tetyana…[et al.]. 2014. Stem Cell Niches in Glioblastoma : A Neuropathological View. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-493702
Modern Language Association (MLA)
Schiffer, Davide…[et al.]. Stem Cell Niches in Glioblastoma : A Neuropathological View. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-493702
American Medical Association (AMA)
Schiffer, Davide& Mellai, Marta& Annovazzi, Laura& Caldera, Valentina& Piazzi, Angela& Denysenko, Tetyana…[et al.]. Stem Cell Niches in Glioblastoma : A Neuropathological View. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-493702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493702