Sensitive Label-Free Biomolecular Detection Using Thin Silicon Waveguides
Joint Authors
Lopinski, G.
Xu, D.-X.
Waldron, P.
Janz, S.
Cheben, P.
Schmid, J. H.
Lapointe, J.
Mischki, T.
Densmore, A.
Delâge, A.
Source
Advances in Optical Technologies
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-06-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Engineering Sciences and Information Technology
Abstract EN
We review our work developing optical waveguide-based evanescent field sensors for the label-free, specific detection of biological molecules.
Using high-index-contrast silicon photonic wire waveguides of submicrometer dimension, we demonstrate ultracompact and highly sensitive molecular sensors compatible with commercial spotting apparatus and microfluidic-based analyte delivery systems.
We show that silicon photonic wire waveguides support optical modes with strong evanescent field at the waveguide surface, leading to strong interaction with surface bound molecules for sensitive response.
Furthermore, we present new sensor geometries benefiting from the very small bend radii achievable with these high-index-contrast waveguides to extend the sensing path length, while maintaining compact size.
We experimentally demonstrate the sensor performance by monitoring the adsorption of protein molecules on the waveguide surface and by tracking small refractive index changes of bulk solutions.
American Psychological Association (APA)
Densmore, A.& Xu, D.-X.& Janz, S.& Waldron, P.& Lapointe, J.& Mischki, T.…[et al.]. 2008. Sensitive Label-Free Biomolecular Detection Using Thin Silicon Waveguides. Advances in Optical Technologies،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-493708
Modern Language Association (MLA)
Densmore, A.…[et al.]. Sensitive Label-Free Biomolecular Detection Using Thin Silicon Waveguides. Advances in Optical Technologies No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-493708
American Medical Association (AMA)
Densmore, A.& Xu, D.-X.& Janz, S.& Waldron, P.& Lapointe, J.& Mischki, T.…[et al.]. Sensitive Label-Free Biomolecular Detection Using Thin Silicon Waveguides. Advances in Optical Technologies. 2008. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-493708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493708