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Association between Serum Interleukin-6 Concentration and Mortality in Patients with Coronary Artery Disease
Joint Authors
Li, Xinrui
Chen, Yu-ming
Zhang, Yuan
Ding, Ding
Deng, Xueqing
Ling, Wenhua
Xia, Min
Su, Dongfang
Qiu, Jian
Li, Zhongxia
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To evaluate whether serum interleukin-6 (IL-6) is associated with increased risk of mortality in coronary artery disease (CAD) patients.
Methods.
We performed a prospective cohort study of 718 CAD patients from the Guangzhou Cardiovascular Disease Cohort (GCDC) study.
Multivariable-adjusted Cox proportional hazards regression analyses were used to examine the association between serum IL-6 with all-cause and cardiovascular mortality.
Results.
During the 1663 person-years of followup, the cumulative all-cause mortality and cardiovascular mortality were 6.5% (n=47) and 3.3% (n=24), respectively.
The mean length of followup was 2.32±0.81 years.
In the multivariable analyses, a one-SD increment in log-transformed serum IL-6 was positively associated with an increased risk of all-cause and cardiovascular mortality, with hazard ratios (HR) of 2.93 (95% CI, 2.11–4.08) and 2.04 (95% CI, 1.34–3.68) within the patients combined and 2.98 (95% CI, 2.12–4.18) and 3.10 (95% CI, 1.98–4.85) within males, respectively.
Patients in the highest serum IL-6 tertile versus the lowest tertile were at higher risk of all-cause and cardiovascular mortality, with HR of 17.12 (95% CI 3.11–71.76) and 8.68 (95% CI, 1.88–37.51), respectively.
Conclusions.
In hospitalized patients with CAD, serum IL-6 is significantly associated with all-cause and cardiovascular mortality.
American Psychological Association (APA)
Su, Dongfang& Li, Zhongxia& Li, Xinrui& Chen, Yu-ming& Zhang, Yuan& Ding, Ding…[et al.]. 2013. Association between Serum Interleukin-6 Concentration and Mortality in Patients with Coronary Artery Disease. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-493729
Modern Language Association (MLA)
Su, Dongfang…[et al.]. Association between Serum Interleukin-6 Concentration and Mortality in Patients with Coronary Artery Disease. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-493729
American Medical Association (AMA)
Su, Dongfang& Li, Zhongxia& Li, Xinrui& Chen, Yu-ming& Zhang, Yuan& Ding, Ding…[et al.]. Association between Serum Interleukin-6 Concentration and Mortality in Patients with Coronary Artery Disease. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-493729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493729